About Flagyl: Flagyl contains the active ingredient Metronidazole. It is an antibacterial and anti-amoebic drug used in the treatment of amoebic dysentery. It also has good activity against anaerobic organisms and is used in circumstances where anaerobic infection is suspected to be likely or is proven. Flagyl is a first of this class of antibacterials originally developed from nitroimidazole which was introduced in 1959 for the treatment of Trichomoniasis. Flagyl was later found to be an effective amoebicide and this became its most widespread use. It also has broad spectrum activity against protozoa. Flagyl is selectively toxic to anaerobic microorganisms such as Bacteroides fragilis, Fusobacterium, clostridium perfringens, Cl. difficile, H. pylori, Campylobacter, peptococci and peptostreptococci. It facilitates the removal of the worm Dracunculus medinensis in Guinea worm infestation. Flagyl is not effective against aerobic bacteria.
How Flagyl Works: Flagyl (Metronidazole) is an antibacterial and antiamoebic agent, and is drug from the group of nitroimidazole compounds. It is selectively toxic to anaerobic organisms since it requires an anaerobic environment for proper functioning and its cidal action. After entering the cell via diffusion, the nitro group of Flagyl is reduced to nitro radical by certain redox proteins found only in anaerobic organisms. This nitro radical exerts its cytotoxic activity. This radical competes with the natural electron acceptors present the cell of the organism and prevents the functioning of the pyruvate ferredoxin oxidoreductase pathway. Flagyl thus prevents pyruvate oxidation and the energy metabolism of anaerobic organisms is disrupted. An aerobic environment does not allow Flagyl to be activated by the reductive mechanism. When an organism becomes resistant to Flagyl, it becomes deficient in the mechanism that is used to generate toxic nitro radicals from it.
How To Take Flagyl: Flagyl Online is used in the management of anaerobic infections as well as amoebic infestations, which can be localised or systemic. It is used in the treatment of Trichomoniasis, bacterial vaginosis, giardiasis, ulcerative stomatitis, as part of treatment for H. pylori induced gastritis and as part of regimens for preparation of bowel for surgery. Buy Flagyl Online Canada is supplied as 800 mg and 400 mg tablets for oral consumption. An injectable form is also available and is used in the strengths of 500 mg/ 100 ml and 250 mg/ 100 ml. For the topical treatment of wounds and infections as well as intravaginal use, Flagyl Canada creams and jelly preparations are available. The recommended dose for the management of dysentery of amoebic aetiology is 400-800 mg taken 3 times a day after meals. The duration of therapy is usually 5-7 days. In the management of systemic amoebiasis and liver infestations and abscesses, Buy Flagyl Online can be used in the injectable intravenous form at 500 mg 6 hourly till the patient can be resumed on tablet medication. In the treatment of Trichomoniasis, Buy Flagyl is administered as a single dose of 2 gm or as divided doses in a single day. Buy Flagyl Canada is also the first line treatment of pseudomembranous colitis, and is given in double dose of 800 mg 3 times a day via oral route. When used for the treatment of other serious infections with anaerobic bacteria, Flagyl is given intravenously at 7.5 mg/kg at a 6 hourly interval.
Precautions And Side Effects Of Flagyl: Buy Flagyl can produce a Disulfiram like reaction and should be avoided in alcoholics for fear of dangerous adverse effects. It is not recommended for use in patients with blood dyscrasias and porphyria, those with neurological illness and in pregnancy in the 1st trimester. Dose reduction of Flagyl Online and use with caution is warranted in patients with hepatic dysfunction or renal impairment.
Flagyl Canada can commonly cause effects like GI disturbances, bad taste, myalgias, headache, dizziness and rashes. Serious effects of Buy Flagyl Online include hepatic dysfunction, neuropathy and CNS effects like seizures.